Hydrophilic Matrix Tablets Essay Example

Hydrophilic Matrix Tablets Essay Example Hydrophilic Matrix Tablets Essay Hydrophilic Matrix Tablets Essay How Changes in the Formulation of Hydrophilic Matrix Tablets Effects Drug Release and Tablet Hydration Discussion: Part A ( hydration ) : Experiment A1: Experiment A1 was carried out to see how the belongingss of different polymers consequence the hydration of hydrophilic matrix tablets. Four different polymers were tested Sodium Alginate 100 % ( SA ) , Xanthan Gum 100 % ( XG ) , Hydroxypropylmethylcellulose 100 % ( HPMC ) and Methylcellulose 100 % ( MC ) . These were compared to a control which was a standard lactose tablet. They were all tested in fake stomachic fluid ( SGF ) and fake enteric fluid ( SIF ) individually. First if we compare all the matrix tablets to the milk sugar we can see that the lactose tablet wholly disintegrates with in the first 30mins in both fluids. However the matrix tablets barely disintegrate and are still present at 240mins. This is because the lactose tablet does non incorporate a polymer. Upon initial wetting of the matrix tablets the polymer begins to hydrate organizing a syrupy gel bed. In order for drug to be released it has to spread through this bed. This takes clip and this allows sustained dru g release. Whereas the lactose tablet merely disintegrates and releases all the drug straight off. Sodium alginate ( SA ) is a natural hydrophilic polyose and is a additive polymer. We can see from the consequences that it was quickly able to organize a gel bed nevertheless the size of the gel bed was different in the two fluids. SA formed a larger gel bed in the SGF than the SIF as it got to 4mm in the SGF and merely 2.5 in the SIF. It besides took longer for the gel to increase in size in the SIF. The nucleus breadth decreased as clip went on and were similar for both fluids but overall it was somewhat lower in the SGF at the clip points. The difference in the breadth of the gel bed between the two fluids shows that the hydration of SA is dependent on pH. SIF has a pH of around 7.2 so is impersonal nevertheless SGF has a pH of around 2 to 3 doing it acidic. As the concentration of H ions addition ( in acidic conditions ) there is inter-conversion of carboxylate anions ( sodium alginate ) to free carboxyl groups ( alginic acid ) . This means in acidic conditions like SGF SA is ab le to swell but is indissoluble nevertheless it is soluble in impersonal conditions. Therefore the gel bed may acquire dissolved in SIF and consequence in a lower breadth compared to SGF which would hold a thick gel bed. Hence alterations in pH are likely to change the hydration features of the polymer and consequence its action on sustained drug release. Xanthan gum ( XG ) , an anionic polymer, showed different hydration features compared to SA. It produced the widest gel bed the fastest at 30mins compared to the other polymers in both the fluids. This shows its ability to organize a thick gel bed rapidly. It was besides able to bring forth the widest gel bed in the SIF compared to the other tablets. It had similar features in both fluids which indicated it is non pH dependant. The nucleus breadth is besides similar in both. HPMC besides was able to organize a gel bed nevertheless its size increased the slowest in both fluids when compared to the other polymers. It is non pH dependant. Again the nucleus was similar in both. Cellulose is really soluble and porous this could be why the gel bed was non really thick Methylcellulose ( MC ) was besides able to organize a gel bed and had similar consequences for both gel and nucleus breadth in both fluids. To reason Quick hydration and subsequent gel formation is a foremost and of import belongings of a polymer for it to be used for sustained release preparation. This is due to the thought that if the polymer does non hydrate rapidly, the surface barrier ( gel bed ) can non be formed instantly, which may do a big sum of drug to be released during the fast initial stage. Besides the thicker the bed the better this is because the more the matrix crestless waves, the longer the diffusion way length required for the drug to come out, which consequences in decreasing of release rate. Therefore all four tablets are acceptable to be used as hydrophilic matrices as they all form a gel bed but out of all four matrix tablets I believe XG to hold the best hydration features as it forms the quickest and thickest gel bed. There were a few restrictions. Cuting the tablets may hold affected the measuring of breadth, tabular arraies were hard to manage when nucleus was little and gel bed was big and finding the waterlessness of the nucleus was hard. Experiment A2: The purpose of experiment A2 was to see how different concentrations of polymer effected hydration of the matrix tablet. By and large the tendency shows that as you increase the concentration of polymer the rate of hydration lessenings. The consequences for the two fluids were similar nevertheless the hydration rate was somewhat greater in SGF. 5 % of polymer was excessively small to even organize a gel bed and therefore the tablet disintegrated directly off. At 10 % there was rapid formation of a gel bed nevertheless the nucleus breadth was low and the nucleus was wet bespeaking a high rate of drug release and the tablet disintegrated by 240mins. For 15, 20 and 30 % a gel bed did signifier at a slower rate severally but at that place was a higher nucleus breadth and the nucleus was drier. To reason, the greater the concentration of the polymer the thicker the gel bed. However it takes longer to organize. When the concentration of HPMC is low the gel bed is non thick and the hydrous matrix would be extremely porous with a low grade of tortuousness taking to low gel strength and rapid diffusion of the drug from matrix. Besides the addition in lactose at low concentrations of polymer agencies that it disintegrates faster. At high concentrations the matrix is more compact and the intermolecular interactions between the polymer means it is less porous so it takes longer to hydrate but when it does it organize a thick syrupy bed forestalling increased drug release. I believe at that place needs to be a via media between the rate of hydration and drug release. Therefore the best concentration to utilize would be about 20 % as it is able to organize a gel bed within 30mins and forestall a high rate of drug release. The restrictions for this experiment were similar to those fr om A1 Experiment A3: Experiment A3 involved the usage of the decomposition rigs. The thought of this trial was to see how polymer concentration effects hydration and decomposition of hydrophilic matrix tablets. The decomposition of three different concentrations ( 5, 15 and 30 % ) of SA, XG and HPMC were tested in SGF and SIF. For SA the general tendency showed that as polymer concentration increases the tablet disintegrates less. As discussed above in SGF SA forms an indissoluble polymer which makes it thicker than the bed in SIF. Therefore it would take longer for fluid to perforate the tablet in SGF and that is why it disintegrates quicker in SIF. In SIF it to the full disintegrates by 45mins for all concentrations but the tablet is still present in the SGF at this clip. For XG none of the tablets in both fluids managed to disintegrate. Disintegration was faster in SGF. This could be due to the sourness of the SGF. For SIF all three different concentration seemed to demo the same decomposition profile. As concentration increased in SGF the clip taken for decomposition increased like SA. For HPMC the consequences were surprising. For both the fluids all the concentrations of HPMC disintegrated wholly within the first hr and no gel bed was observed. Decomposition was faster in SIF. For SGF it took longer at higher concentrations. Therefore it did non demo sustained release belongingss like XG and SA. There were many restrictions. Exact clip of decomposition was difficult to find due to the clip intervals. Two different people were taking consequences so they would hold different subjective positions. Besides the graduated table used was obscure. The tablets could hold been assayed and more concentrations should hold been tested. Part B ( drug release ) : Part B was used to prove the drug release belongingss of hydrophilic matrix tablets. In order to make this the consequences obtained from the basket disintegration setup will be compared to the consequences from the flow rig setup. This will let us to find which disintegration method is more accurate every bit good as comparing their variableness. Revolving basket: If we look at the graph that shows the sum of drug released against clip. We can see that every bit shortly as the lactose tablet is inserted into the SIF there is an initial explosion of drug release. The sum of drug released continues to increase at a fast rate until around 30min where it begins to plateau and so lessening. The drug is released rapidly from the lactose tablet as there is no gel bed formed to decelerate the diffusion of drug out. Therefore the fluid rapidly disintegrates the milk sugar and all the drug is released. For the polymer tablet there is once more an initial explosion of drug release precisely the same as the lactose tablet. This is because the gel bed has non formed yet. Once the bed forms the sum of drug released begins to diminish compared to the control. It plateaus at around 15mins and so continues to let go of the same sum of drug for the remainder of the experiment. Therefore drug release continues for a longer period indicating sustained release. The rate of drug released for both the tablets start high and so bit by bit decreases. For the control the rate of release is ever greater than that of the polymer shown by the graph. For the control the drug is released quickly until there is none left. With the polymer it shows good modified release as the rate is a batch lower and is comparatively changeless between 5 to 15 mins. Flow -through rig: The flow rig showed clear conclusive consequences about the release profiles for the two different types of tablets. If we look at the graph demoing concentration of drug release over clip we can see directly off the modified release features of the polymer tablet. For the control every bit shortly as the rig is turned on we get immediate drug release. It continues to lift quickly until 10min and so begins to diminish until 60min where it is so wholly disintegrated. Both the tablets had disintegrated wholly. For the polymer we can once more see an initial explosion of drug release. This is because the gel bed has non formed. After 5 min one time the bed has formed the graph tableland and there is a changeless sum of drug released until 120min nevertheless the concentration of drug released is a batch lower than that of the control. When compared to the control there is a clear difference in the two release profiles. The two rigs both analysed the same thing but both had differing methods and gave different consequences. The basket method was simpler to put up and less fiddly to take consequences. However there were restrictions. Air bubbles on the basket could hold altered drug release, it was hard to reel the readings and during the start the clip intervals were really close together doing it difficult to take all the readings. The flow rig besides had drawbacks. First our setup 3 flow tubings were leaky. This meant that merchandise would hold been lost. Besides for one of the control rig the flow rig stopped working and no more consequences could be taken. Therefore we were unable to add mistake bars to the control graph. Finally merchandise may hold been lost when reassigning the pipes. Besides for both the experiments they did non mime the proper physiological conditions that would be present in the organic structure. If we compare the two methods I believe the flow-through rig gave more acc urate dependable consequences. The mistake bars were greater in the basket method significance at that place was a batch of fluctuation and the consequences would be hard to reproduce. Besides for the flow rig both groups showed indistinguishable consequences this was non the instance for basket. The flow rig showed the concentration of drug released at precisely the clip specified whereas the basket method shows the entire sum of drug released by the tablet at the specific clip so it is cumulative. Therefore the consequences for the flow rig are more good and manageable as the one graph gives all the needed information. Besides if the tubings were crystalline we could see the tablet. A reciprocating cylinder was besides used to prove drug release. Even though it mimics physiological conditions the best it provided inconclusive consequences in SIF for SGF it once more showed a lower rate of drug release for the polymer. However the mistake bars were really big for all the consequences and hence non accurate. Decision: By comparing the consequences from all the experiments we can reason Xanthan Gum is the best polymer to utilize for sustained release preparations, nevertheless all the polymers used produced acceptable hydrophilic matrices. XG had the most advantageous hydration profile compared to the other polymers as explained in the decision of portion A1. It can besides be seen that concentration of the polymer has an consequence on hydration explained in the decision of portion A2. XG showed sustained release at all concentrations but 15 % would be the best via media between decomposition clip and drug release. Finally drug release from tablets with polymers can clearly demo sustained release when tested by many different disintegration rigs nevertheless the flow-through rig proved to be the most successful.

Base and Superstructure Definition of Marxs Terms

Base and Superstructure Definition of Marxs Terms Base and superstructure are two linked theoretical concepts developed by Karl Marx, one of the founders of sociology. Simply put, base refers to the forces and relations of production- to all the people, relationships between them, the roles that they play, and the materials and resources involved in producing the things needed by society. Thomas Lohnes / Getty Images Superstructure Superstructure, quite simply and expansively, refers to all other aspects of society. It includes culture, ideology (world views, ideas, values, and beliefs), norms and expectations, identities that people inhabit, social institutions (education, religion, media, family, among others), the political structure, and the state (the political apparatus that governs society). Marx argued that the superstructure grows out of the base, and reflects the interests of the ruling class that controls it. As such, the superstructure justifies how the base operates, and in doing so, justifies the power of the ruling class. From a sociological standpoint, it’s important to recognize that neither the base nor the superstructure is naturally occurring, nor are they static. They are both social creations (created by people in a society), and both are the accumulation of social processes and interactions between people that are constantly playing out, shifting, and evolving. Extended Definition Marx theorized that the superstructure effectively grows out of the base and that it reflects the interests of the ruling class that controls the base (called the â€Å"bourgeoisie† in Marx’s time). In The German Ideology, written with Friedrich Engels, Marx offered a critique of Hegel’s theory of how society operates, which was based on principles of Idealism. Hegel asserted that ideology determines social lifethat the reality of the world around us is determined by our mind, by our thoughts. Historical Shifts to a Capitalist Mode of Production Considering historical shifts in relations of production, most importantly, the shift from feudalist to capitalist production, Marx was not content with Hegel’s theory. He believed that the shift to a capitalist mode of production had sweeping implications for the social structure, culture, institutions, and ideology of society- that it reconfigured the superstructure in drastic ways. He posed instead a â€Å"materialist† way of understanding history (â€Å"historical materialism†), which is the idea that the material conditions of our existence, what we produce in order to live and how we go about doing so, determines all else in society. Building on this idea, Marx posed a new way of thinking about the relationship between thought and lived reality with his theory of the relationship between base and superstructure. Importantly, Marx argued that this is not a neutral relationship. There is a lot at stake in the way the superstructure emerges out of the base, because as the place where norms, values, beliefs, and ideology reside, the superstructure serves to legitimate the base. The superstructure creates the conditions in which the relations of production seem right, just, or even natural, though, in reality, they may be deeply unjust, and designed to benefit only the minority ruling class, rather than the majority working class. Marx argued that religious ideology that urged people to obey authority and work hard for salvation in the afterlife was a way in which superstructure justifies the base because it generates an acceptance of one’s conditions as they are. Following Marx, Antonio Gramsci elaborated on the role of education in training people to obediently serve in their designated roles in the division of labor, depending upon into which class they were born. Marx and Gramsci also wrote about the role of the state- the political apparatus- in protecting the interests of the ruling class. In recent history, state bailouts of collapsing private banks is an example of this. Early Writing In his early writing, Marx was very committed to the principles of historical materialism, and the related one-way causal relationship between base and superstructure. However, as his theory evolved and grew more complex over time, Marx reframed the relationship between base and superstructure as dialectical, meaning that each influences what happens in the other. Thus, if something changes in the base, it causes changes in the superstructure, and vice versa. Marx believed in the possibility of a revolution among the working class because he thought that once workers realized the extent to which they were exploited and harmed for the benefit of the ruling class, then they would decide to change things, and a significant change in the base, in terms of how goods are produced, by whom, and on what terms, would follow.

Bank Annual Report Assignment - Economics Essay Example | Topics and Well Written Essays - 500 words

Bank Annual Report Assignment - Economics - Essay Example Other mining activities accounted for ASD 0.83 billions forming 0.22% of the total GDP.Thus taking the contribution of mining industries to 32.78 %( Annual 2004). Annual Report of the Central Bank of United Arab Emirates for the year 2004 has the data at Table (2-1) that Manufacturing and Construction Sectors contributed ASD 70.43 billions to 2004 GDP at constant prices of ASD 323.60 billions. In percentage terms this contribution came to 21.76 %( rounded off to 22%). Table(2-2) of the Annual report further shows that Manufacturing and Construction Sectors contributed ASD 78.02 billions to 2004 GDP at current prices of ASD 378.61 billions. In percentage terms this contribution came to 20.61 %( Annual 2004). Table(2-8) ,captioned 'Employees by Economic Sectors' , of the Annual Report of the Central Bank of United Arab Emirates for the year 2004 has the data that UAE had a total of 2.46 million employees in UAE in 2004.Of this 0.27 million were engaged in the Government Sector forming about 10.98% of the total employees. As against this Oil& Gas, and Manufacturing sectors deployed 0.35 million employees which formed about 14.23 % of the total employees (Annual, 2004).Thus more number of employees were deployed in Oil& Gas, and Manufacturing sectors when compared to the Government Sector.

Segregation of Schools on the Basis of Gender Research Paper

Segregation of Schools on the Basis of Gender - Research Paper Example Smyth (47) observes that several countries, including Australia, New Zealand, and Ireland, continue to have a sizeable number of single-sex schools, where boys and girls receive education at separate classrooms. However, some of the educational centers vehemently turn down any possibility for the mixing of genders at schools. Consequently, they recommend and enforce segmentation of the children on the basis of their gender. In few of the most developed countries, such as the UK, USA, Canada, and India, the students obtain learning classes under one roof without their segregation on a gender basis. The co-educated schooling is actually exercised on the foundation of the Title IX of the U.S. Education Amendments as of 1972, which vehemently outlawed discrimination on the basis of sex in educational programmes receiving federal funds (Halpern et al.) Thus, the U.S. law absolutely rejects the possibility of segregating the schooling of the children in the light of their gender difference s. Theorists maintain different opinions about the co-education and segregated patterns of education for adolescents and young students. Some of the critics declare segregation of educational centers on gender basis as strictly against the norms, values, traditions, and customs which have been prevailing in the contemporary world for the last several decades. They also cite the example of the division of society on the basis of race, ethnicity, and religion, where people get their children admitted to the schools that belong to their own ethnic-racial background. They stick to the opinion that segregation of boys and girls at schools not only paves the way towards the further splitting up of the already divided society but also disables the young generation from comprehending the challenges they are to undergo as professionals in future. The supporters of co-education schooling declare segregation of the students on the basis of gender as strictly against the principles of gender eq uality. Since the statutes of law condemn the practicing of any ethnic, racial, religious or gender discrimination, depriving the children of getting admission into the schools of their choice is absolutely against the basic rights the Human Rights Charter bestows upon them. Since all boys and girls are free to enjoy their human rights and their potential as individuals in economic, socio-cultural, civil and public life, no law can forbid them to enter into the learning process of their choice altogether. In addition, since boys and girls are to become partners at domestic and career life, they have to be able to enter into decisions making in collaboration with one another so that to secure peace and harmony in their homes, communities, and societies. Schools have an important role to play in preparing girls and boys to listen and communicate effectively with each other in order to build this respectful partnership (UNESCO, 2007). Thus, since men and women are to perform all obliga tions and activities, in political, economic, social and cultural fields, they should learn to behave with each other under healthy and competitive environment principles.

Corporate governance Essay Example for Free

Corporate governance Essay Introduction Corporate governance refers to a system of mostly rules, practices as well as procedures that direct as well as control a company. In most cases it involves the balancing of all the stakeholders that have an interest in the company including the management, shareholders, government, the community to mention but a few depending on the company. Essentially, corporate governance provides a framework that if followed will help the company attain its objective in an all round manner. Though a relatively new phenomenon, this concept has been able to take the world by storm with countries that have embraced it turning in a lot of development that their counterparts. The embracing as well as the internalization of corporate governance by different countries has been able to foster growth and development while creating a business friendly environment in which companies can co-exist with the state as well as the communities in which they operate (Fernando, 2009, p.23). Case study: the United States As recent as 2002, the United States enacted the Sarbanes-Oxley bill into law making it an act. This was ushered in to restore the public’s confidence in companies and markets. Prior to this act, there had been a string of bankrupted high profile companies that had been brought down by internal accounting fraud. This left a twist that ensured that the companies would essentially be governed by state laws and therefore failure due to breach of such laws would be answerable to the government. This ensures that not only are the interests of the company shareholders protected but that then community that usually benefits from activities such as employment are also taken care off. Thus, the country has over years adopted different legislations both at the federal as well as state level that ensure that corporate governance is fully realized in the state. Therefore, from the United States, the UK can learn to enact strong legislations that would act as a guidelines to both state as well as the companies and any other stakeholders of the importance of embracing corporate governance. This would also serve the purpose of regulating corporations that will then have to acknowledge the fact that rules have been put in place and therefore have to be followed and that failure of compliance would lead to outlined penalties (Chew Gillan, 2009, p. 3). Case study: India India, unlike the United States, has created a committee that deals with corporate governance know as the Securities and Exchange Board of India (SEBI). The board that in most cases takes on a trustee role for all the companies in India was created through the adoption of SEBI Act, 1992. The act gives the body statutory powers to be able to carry out its duties and functions. These approach adopted in India is believed to have been adopted from the Ghanaian principle of trusteeship and that it is a directive of the Indian constitution with a little twist in between. The preamble of the body is to among other functions â€Å"†¦to protect the interests of investors in securities and to promote the growth (Das, 2008, p. 7). Reference Chew, D. H., Gillan, S. L. 2009. U.S. corporate governance. New York, N.Y., Columbia   Ã‚  Ã‚  Ã‚   University Press. Das, S. C. 2008. Corporate governance in India: an evaluation. New Delhi, Prentice-Hall of   Ã‚  Ã‚  Ã‚   India. Fernando, A. C. 2009. Corporate governance: principles, policies and practices. New Delhi,   Ã‚  Ã‚   Pearson Education.

Daily Athenian life :: essays research papers fc

  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   â€Å"Famed for its literature, poetry, drama, theatre, schools, buildings, government, and intellectual superiority you have no doubt that your polis, Athens, is clearly the shining star of all Greek city-states.†(Daily life in ancient Greece) Athens was a mighty city-state of Greece. Even though it was a very intellectual and powerful city-state, it did not mean that it was necessarily a good city. Athens was the cause of the Peloponnesian War. It deceived the other city-states by making them send money to Athens, so Athens could build a powerful army to protect Greece from the Persians. Athens started to use that money on the city of Athens. Eventually the citizens of Athens did not have to pay taxes. The other city-states got angry, thus beginning the Peloponnesian war. The war lasted about 30 years, starting from 461-406 BC.   Ã‚  Ã‚  Ã‚  Ã‚   An aristocrat named Cleisthenes, who was trying to gain more power, invented a form of government called democracy. Democracy was used in Athens. Athens was lead by a great statesman named Pericles. He died during the war because of disease. Many people died of the same disease. After the war, Sparta set up a government of thirty tyrants. Two of the tyrants were students of the renowned philosopher, Socrates. That stirred up some controversy later with Socrates and the Athenian aristocrats. A year later the democratic form of government was restored, and the Athenian government went back to normal. Men were prominent figures of government. Women were thought to be foolish and irrational, which we all know is not true. â€Å"Men, in the Greek view, were rational, thinking, stable, normal creatures, while women were irrational, hysterical, and dangerous.†(History for kids) Women for that reason were not given political rights. Athens had good soil, since it was near the coastline. They also had just enough rainfall, not too much or too little. They grew grain, grapes, olives, legumes, lentils, beans and chickpeas. The Athenians believed in many gods, just like all the other people of Greece. They had 7 seven main gods. The most important of all the gods was Zeus, the king of the gods, who was married to his sister Hera. The gods had humanlike characteristics; they got jealous and would do stupid things just like humans do.

Promote equality and inclusion in health, social care or children’s and young people’s settings Essay

1. Explain what is meant by Diversity, Equality and Inclusion Equality Equality is the term for treating people fairly and offering the same chances, it’s not all about treating everyone in the same way, but recognising everyone is different, and they all have very different needs, but making sure they are met. These different needs could be race, age, physical health, mental health, gender, sexual orientation, beliefs and creeds. In the workplace, there are many service users, 13 altogether, and each of them have a variety of needs. Some with dementia, others with epilepsy, a group of down syndrome, people of the age of 20 rights through to 70, people with diabetes. DiversityWhere equality is about recognising differences, diversity is about valuing these differences, for example not to along ago a service user came in on respite, he was of an Islamic background. With this there were certain values that came part and parcel of the religion, these were the consumption of Halal meat, praying five times a day and wearing specific clothing. InclusionInclusion is the term used to define the ability to adapt and place measures so that everyone, no matter what their needs are they can participate. see more:equality and diversity in health and social care Many service users hope and want to lead extremely active lifestyles. So with regards to an activity such as the gym, as part of our responsibility 2. Describe the potential effects of discrimination To see the possible effects of discrimination fully, it’s best to look at how it affects from a holistic perspective. With regards to discrimination affecting physical health, this can be a by product of stress and depression. A lot of physical problems can be stress induced such sleeplessness and from this you can end up with a lack of energy, headaches, ulcers. Depression can affect eating habits, getting into the routine of comfort eating; this then would cause weight problems. For those suffering from severe depression it can lead to self harm. From this you can get a massive lack in confidence in one’s own ability, this can then begin to impede on emotional aspects and mental well being. One can almost feel that they lack a voice or authority, a feeling of people unwilling to listen to them. Inducing low self esteem, insecurity, lack of confidence and sudden changes in behaviour. Social effects can include isolation, lack of friends, withdrawing one’s self from society, unrecognized as an individual, feel like a stranger and inability to build relationships. If being discriminated against, the intellectual effects can be massively restricted; this could be a lack of access to education, leading to poor grades in exams or portfolios, a loss of motivation which can impede a wide variety of skills and a lack of self belief. 3. Explain how inclusive practice promotes equality and supports diversity As my role of activities co-ordinator it is absolutely vital that the service users like you or I have the same opportunities. One activity where the organisation is clearly demonstrating is a club called Gresford Scottish Bowls. This club is unique in the sense that there are only about 3 in the UK. However it is not an exclusively LD group. The club opened its doors to about 5 service users. It is a game intricate skill, now it is very rare, and I have had lots of problems with group allowing service users to join. The service users have taken to it very well, one is a sub-skip of a team, one service user won the singles championship. By allowing them this opportunity it breaks the negative barrier held by mainstream society and in this example by including them they have an equal opportunity, and demonstrate that they are more than capable of holding their own. Another example is getting two service users enrolled into the local college, it is a basic human right that every human is allowed to have an education. Though specific measures need to be taken, such as support staff, assistance with the work, they get that equal opportunity. On a larger scale however, the organisation has just taken a massive step forward. This is to do with the funding for one on one hours. The manager has managed to gain equal one on one hours for every service user. This means that for once in the organisations existence they can provide an equal service, to each individual and the will all have an equal amount of support. This is demonstrates inclusive practice leading to equality, however each set of hours can be different for each service user which embraces diversity.

“Optimal Versus Naive Diversification: How Inefficient Is the 1/N Portfolio Strategy” †a Critique

â€Å"Optimal Versus Naive Diversification: How Inefficient Is The 1/N Portfolio Strategy† – A Critique Title: The title of the paper â€Å"Optimal Versus Naive Diversification: How Inefficient Is The 1/N Portfolio Strategy† has been reasonably well phrased.However, it can be argued that the title is a little misleading as the principal objective of the paper is to test how efficient different optimal diversification strategies are using the 1/N portfolio strategy as the benchmark and not to try and elucidate the merits of the 1/N strategy, which the authors are certainly neither advocating for practical purposes nor seemingly seeking to foster greater intellectual attention on the simplistic strategy. The title could have simply been â€Å"How Efficient Really Are Today’s ‘Optimal’ Diversification Strategies? But, care has to be taken before coming to the above conclusion that the authors might have appreciably so, intentionally used the tit le they have in order to attract further attention to their paper by stressing the obvious irony and possible iconoclasm in their conclusions. Abstract: The abstract has been very well written. It captures the essence of the study and conveys the crux of it lucidly to the reader. However, it would have augured better to start the abstract by stating the objective of the study in addition to it being mentioned in the text of the article just as the authors have.That way, the abstract would have had greater clarity. Motivation: The inherent motivation behind the study is laudable and the implied motivation derived from the conclusion is obvious. However, the motivation itself has unfortunately not been sufficiently expressed. Apart from a one-sentence objective, nothing else has been explicitly written about why the study was undertaken. There is one other sentence, which could be construed as the motivation. But, the authors themselves have not given the sentence the same attribute. The sentence itself is a reference to a revious study that found that many investors used the 1/N diversification strategy ignoring several other sophisticated theoretical models and is stated to only justify their usage of the 1/N diversification strategy as the benchmark. It could have been elaborated upon with additional related facts and further evidence supported by literature. Also, a separate paragraph with a heading called â€Å"Motivation† would be desirable to the readers. Introduction: The topic covered by the article has been adequately introduced. The brief description of the various asset allocation models and how they are related to each other is commendable.The introduction has also carefully introduced the methodology, the observations and the results and the conclusions in a logical and concise manner such that readers might understand the study by just reading this part. However, the literature on the Bayesian and non-Bayesian approaches has only been brief ly mentioned in one paragraph. Considering how significant the contribution of the stated articles to the current study might be, it would have only been fitting to include a section called ‘Literature Review’ elaborating on them substantially more than the authors have.That way, they could have been able to make a clearer connection on how the previous studies relate to the motivation and methodology of their study. However, it should be noted that word limits might have been a constraint. In addition, the introduction must be a definite section that is called ‘Introduction’. Methodology: The authors have adopted a robust methodology to evaluate the performance of the diversification strategies discussed. They have been explained in great detail with sufficient appendices in an easily understandable format.There is not much scope for improvement in the methodology and the authors must be greatly appreciated for it. Data: The data has been obtained from hig hly reliable sources, thereby implying that there is hardly any margin for error in the data. No bias or subjectivity is evident. The data has been properly classified and well presented. Results: With well-defined methodology and credible sources, the results of the study are factually accurate even though it can be argued that conclusions from the same are a function of their interpretation just as in every other study. However, there is a drawback concerning the same.The authors have only limited themselves to comparing the performance of models of optimal asset allocation that consider moments of asset returns and not other characteristics of the assets. The authors could have included a section within the discussion of their results in which they could have compared their results with that of other similar studies, even if they involved the analysis of fewer diversification strategies, and sought to establish a reasoning behind how the possible differences between the results o f the studies might be related to variations in their respective methodologies or data.They could have also sought to describe how their study and the underlying methodology have helped overcome previous voids in relevant literature. It might have even been advisable to express why their study is more accurate and hence superior to the others if they did think so. In case the study was known, to their knowledge to be unprecedented and unrelated to any comparative study of portfolio diversification strategies, it should have been explicitly stated as the reason why the above-said was not done.But, it has to be noted that the authors have indeed done the above-said, but only with respect to two of their important assumptions, i. e. , Brandt et al (2007)’s approach to constructing the optimal portfolio using cross-sectional characteristics of equity returns and the dynamic asset allocation models of Campbell and Viciera (1999; 2001) and Campbell et al (2003). Conclusions: The co nclusions of the study are definitely iconoclastic and have huge repercussions for the research community.It points out how inefficient the numerous theoretical models that have been developed on portfolio diversification are clearly indicates that an enormous amount of research has to be undertaken to address this serious shortcoming. The conclusions have been expressed concisely and the limitations of the study have been stated. Their recommendation on the direction for further research is well thought out and justified by their findings and is hence highly commendable.

The Top 100 Transportation Jobs to Look for Right Now

The Top 100 Transportation Jobs to Look for Right Now If you’re interested in a career in transportation, or in finding a new career in the field, the tides of the industry are on your side. According to the Bureau of Labor Statistics (BLS), jobs that fall under the category of â€Å"transportation and material moving† are projected to grow through the year 2024, adding hundreds of thousands of jobs. Jobs in transportation can fall under many umbrellas. Check out the most thriving jobs in the field and see if one might be a good fit for you.Air Asset ControllerAir Traffic ControllerAircraft CaptainAircraft Quality Control InspectorAirfield Operations ManagerAirfield Operations SpecialistAirfield Operations SupervisorAirline DispatcherAirport Grounds Operations WorkerAirport ManagerAirport TransporterAirworthiness SpecialistAmbulance DriverAviation ManagerAviation Safety InspectorBoat CaptainBoat OperatorBoom Truck OperatorBulk DriverBus DriverChauffeurClass A DriverClass B DriverConductorCopilotDeck OfficerDock MasterDrive rDriver HelperDriver ManagerDriver SupervisorDriving TeacherDump Truck OperatorEmergency Vehicle DriverEquipment MoverFlatbed Truck DriverFlight AnalystFlight AttendantFlight CoordinatorFlight EngineerFlight InstructorFlight NavigatorFlight SchedulerForklift OperatorGeneral Transportation DirectorHelicopter PilotHousehold MoverJet PilotLocomotive EngineerLog Truck DriverMapping PilotMarine OilerMedical Cylinder DriverMotor Coach OperatorOver the Road Driver (OTR Driver)Owner / OperatorPallet Jack OperatorParking Lot AttendantParking Services SpecialistParking Systems ManagerPassenger Service AgentPatient Transport DriverPick Up and Delivery DriverPilotRail Motor Coach OperatorRamp AgentRelief DriverResidential DriverRoute DriverSailorSanitation DriverService Station AttendantShip CaptainShip Chief EngineerShip NavigatorShip SuperintendentShuttle DriverSimulator InstructorSkycapStacker OperatorStreet Cleaning Equipment OperatorSubway and Streetcar OperatorTaxi DriverTest PilotTest Pi lot ManagerTicket AgentTolling SpecialistTow Truck DriverTrain ManagerTransit DirectorTransit ManagerTransit OperatorTransit PlannerTransportation AideTransportation AnalystTransportation Facility RepresentativeTransportation InspectorTransportation Mobility ManagerTransporterTruck DriverVan DriverWheelchair Van DriverYard HostlerAccording to BLS, the median annual wage for transportation occupations was $30,730 in 2016.Education requirements differ for professions within the transportation field- many ask for no formal education or a high school diploma, while some require a post-secondary degree.This is a varied fields with lots of opportunity nationwide- do some searching to find the perfect position for your career goals!

Strategies for Gathering and Evaluating Sources Essay

Strategies for Gathering and Evaluating Sources - Essay Example The information was last published in the year 2003 and has not been updated of late. There are however other resources that can be found from a variety of books. In addition, the materials found in this article do match the content in most of the other articles. In addition, this article gives case studies that highlight issues that concern censorship in many nations. The author is a music lecturer at the University of Connecticut and has dwelt on the issues affecting censorship for several years. He describes what is already known from other sources and adds little from his personal experiences. The experience that the author has in the field enables him to handle the complexities that arise from the topic under consideration. The information was last published in the year 2006 and has not been updated of late. However, there are other sources that have the latest information regarding censorship in music but which match the content of the article. The article brings forth the newest research concerning the topic of censorship in Africa along with various case studies on the issue. The article focuses on any attempts that are being made in the continent for the purpose of censoring musicians along with the strategies that the musicians have devised for resisting these moves. Nuzum describes what is already known and is unknown in the industry and adds little from his personal experiences. The experience that the author has in the field enables him to handle the complexities that arise from the topic under consideration. The information was last published in the year 2001 and was updated in the year 2008. However, other information sources also have the latest information regarding censorship in music but which matches the content of this article. This book by Nuzum provides details of everything an individual would like to know concerning music including what the parents may not like

Fianance enterpreship Essay Example | Topics and Well Written Essays - 3000 words

Fianance enterpreship - Essay Example The financial manager of the company tries to strike a balance between debt and equity with the aim of maximization of firm value and minimization of cost. It has been seen that the managers are biased in favour of debt owing to the tax benefits associated with debt financing. The interest paid on borrowings is a tax deductible expense. This is the reason the managers prefer debt over equity as it reduces the outflow of the business. However, an excessive reliance on debt is not in the financial interest of the company. An ideal mix of debt and equity is essential. There are various theories on capital structure such as pecking order theory, signalling theory, agency theory, trade-off theory, signalling theory etc. As per the pecking order theory the firm should rely mainly on the internal means of financing like retained earnings. This theory gives credence to retained earnings over the issue of equity. In the event of additional funds requirement the debt mode of funding is preferr ed. The equity issue is used only as a last resort. The main reason for the preference of debt over equity is the lower information costs associated with this mode of funding (Zhao, et al., 2004). The static trade off theory states that the firms try to strike a balance between the benefits associated with interest tax shield and the probability of bankruptcy and failure. The firms with strong cash flows can afford to have high levels of debt as they are assured of fixed future cash flows. But the small sized firms or nascent business firms with limited free cash flows must not use high levels of debt in their capital base. As per the agency theory the managers handle the affairs of the company on the behalf of the company shareholders. This gives rise to agency problems. As the reins of management of the company passes onto the managers and does not remain in the hands of its ‘actual’ owners it gives rise to conflict of interest. It is said that there is a misalignment of the objectives. The managers of the company are accused of investing in risky or unprofitable business ventures instead of passing on the surplus cash flows to the owners (Boodhoo, 2009). On the other hand there is also a view that the shareholders intervene in the smooth functioning of the business which often forces the company to forego lucrative business opportunities. The signalling theory of capital structure suggests that the issue of equity is based on the prevailing market conditions. Suppose the management of the company is of the view that the shares of the company are overpriced then it can resort to the issue of equity. This will help the company in raising higher proceeds from the issue of equity. On the other hand if the managers of the company are of the view that the market has failed to price the shares of the company correctly then it can opt for the debt mode of financing. If the shares of the company are underpriced then it is not feasible to issue equity as this would mean lesser proceeds. It will not just limit the amount of funds raised but will also lead to unnecessary dilution of ownership which is not in the interest of the company from the long term perspective. The financing decisions of a company are influenced by the above theories and views. However the financial managers in a company are biased towards issue of debt owing to the inherent benefits of debt issue. The